Friday, December 23, 2005

 
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So we got a new camera with the Christmas money by dad and susan gave us (Canon Powershot A520), and I've been testing it out. It can even take low resolution movies WITH audio. Cool! Posted by Picasa

Friday, December 16, 2005

Implications of Dedritic Cell Antigen Presentation to B cells

When it comes to Nature magazine, I enjoy it. When my brother got me a subscription I really started to appreciate it. One of the best sections in it is the "Research Highlights", which points out papers that the editors thought where significant but appeared in other journals.

I get the Nature table of contents by email every week, and while I don't always find an interesting article, I always read the research highlights, and that's where this paper came up.
[blockqoute]Cell surface recycling of internalized antigen permits dendritic cell priming of B cells.

Bergtold A, Desai DD, Gavhane A, Clynes R.

Integrated Program in Cellular, Molecular, and Biophysical Studies, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA.

Dendritic cells process internalized antigens to present degradative products on MHC for TCR recognition. Because antigen-exposed DCs also induce humoral immunity, DCs must also retain antigen in its native state for the engagement of BCR on B cells. Here, we demonstrate that antigen endocytosed by the inhibitory Fc receptor, FcgammaRIIB, accesses a non-degradative intracellular vesicular compartment that recycles to the cell surface, enabling interaction of native antigen with BCR on B cells. Immunization with IgG-opsonized, T independent antigens leads to enhanced humoral responses in a FcgammaRIIB and complement dependent manner. IC-loaded DCs trafficking to the splenic marginal zone can prime a T independent response in an FcgammaRIIB-dependent manner. Thus dendritic cells are equipped with both non-degradative and degradative antigen uptake pathways to facilitate antigen presentation to both B and T cells.[/blockqoute]

Why is this important? Previously it was thought that B cells had to be exposed to free, native antigen. This changes the picture, showing that dendritic cells can stimulate both T cells and B cells to activate a robust antibody response. Very cool, and it even has some implications on immunotoxicology (agents that selectively affect dendritic cells may cause significant interference in an antibody response). It remains to be seen how important or widely occuring this phenomenon is, but I think it's pretty cool.

Friday, December 09, 2005

I Love the GPL

So I've got a 700Mb mp3 (an audiobook), and the iPod chokes on big files. What do I do: google search for "split mp3 gpl", and what comes up, but this sweet little free utility that does exactly what I'm looking for, it's called Mp3Splt. That goodness for the GPL (there were plenty of programs in the $20-$30 range that could do that, but who wants to pay for that kind of stuff when I might only use it a single time!).

Tuesday, December 06, 2005

Friends In Far Places

I've been thinking about my friend AJ and his wife Jamie this past weekend. They're teaching elementary children in Honduras right now (they've got a nice website for their adventure), a long way from family. While I'm sure things are a bit warmer there (though I'm not jealous as I look out my office window to see several inches of snow on the ground), I'm thankful that I've got my family around even if it is cold. I'm pretty sure they're ready to see their own families. I know they'll be back for a while over the holidays, and I hope Ellie and I get to see them.

I registered to officiate MHSAA wrestling this year, quite a bit late. Fortunately I didn't have to pay the late fees, as I wasn't registered last year. I just hope I'll be able to pick up some events. Ellie and I are going to need the money to pay for the holidays I think. I'm even thinking about becoming an official for some other sports, but I don't know. I wonder what they pay freestyle/greco roman officals now a days.